Prandin

What is it?

Composition

The main active ingredient in Prandin is repaglinide. Excipients include:

• Dicalcium phosphate (anhydride)
• Microcrystalline cellulose
• Corn starch
• Meglumine
• Croscarmellose sodium
• Povidone
• Poloxamer
• Magnesium stearate
• Colloidal silicon dioxide

Tablets vary in dosage and may contain colorants such as iron oxides to differentiate the doses.

How to use?

Prandin should be taken orally before each main meal. It is usually recommended to take the drug 15 minutes before a meal, but the time may vary from immediately before a meal to 30 minutes before a meal. If you miss a meal, skip the corresponding dose of the drug; if you add an extra meal, add the corresponding dose. It is important to follow the prescribed dosage and schedule to avoid the risk of hypoglycemia or hyperglycemia. Regularly monitor your blood sugar levels and consult your doctor to adjust the dose if necessary.

How does it work?

Prandin works by stimulating the pancreas to produce insulin. It closes the ATP-dependent potassium channels in the beta cell membrane, which leads to cell depolarization and opening of calcium channels. Increased calcium entry into the cell causes insulin secretion. This mechanism helps to lower blood sugar levels after meals, providing more effective glycemic control in patients with type 2 diabetes.

Indications

Prandin is indicated for improving glycemic control in adults with type 2 diabetes mellitus. It is used as an adjunct to diet and exercise to lower blood sugar levels. The drug can be used either as monotherapy or in combination with other hypoglycemic agents such as metformin or thiazolidinediones if monotherapy does not provide sufficient glycemic control.

Contraindications

Prandin is contraindicated in the following cases:

• Type 1 diabetes mellitus
• Diabetic ketoacidosis
• Severe liver dysfunction
• Concomitant administration with gemfibrozil
• Hypersensitivity to repaglinide or any of the components of the drug

Before starting therapy, it is necessary to discuss with your doctor all possible contraindications and concomitant diseases.

Side effects

The following side effects may occur when taking Prandin:

• Hypoglycemia
• Nausea
• Diarrhea
• Headache
• Back pain
• Joint pain
• Cold symptoms such as nasal congestion, sneezing, sore throat

In rare cases, more serious reactions may occur such as jaundice, dark urine, pain in the upper abdomen spreading to the back, nausea and vomiting. If these symptoms occur, you should contact your doctor immediately.