Motilium

What is it?

Composition

Motilium contains the active substance domperidone, which is responsible for the main therapeutic properties of the drug. Domperidone is an antagonist of dopamine receptors, which allows it to effectively combat symptoms associated with slow motility of the stomach and intestines. In addition to domperidone, the drug includes a number of auxiliary components that ensure its stability and ease of use.

Here are the main ingredients included in Motilium:

• Domperidone is the active substance that determines the effect of the drug.
• Lactose - used as an auxiliary substance.
• Corn starch - serves as a binder.
• Magnesium stearate - added to improve the texture of the tablets.
• Povidone - used as a stabilizer.

These components together create a drug that effectively copes with the symptoms of dyspepsia and helps to normalize the functioning of the stomach and intestines.

How to use?

In order to achieve the best therapeutic effect, it is important to use Motilium correctly, as recommended by your doctor or as directed. The drug is usually available in tablet form, which should be taken orally with plenty of water. It is best to take the tablets 15-30 minutes before meals, as this helps the drug work faster and more effectively.

The standard regimen for using Motilium is as follows:

1. Adults and adolescents over 12 years of age are recommended to take 1 tablet (10 mg) 3 times a day. If necessary, the dose can be increased to 2 tablets (20 mg) 3 times a day.
2. For children, the dosage is calculated based on body weight, usually 0.25-0.5 mg per kilogram of body weight 3-4 times a day.
3. The maximum daily dose should not exceed 80 mg for adults and adolescents, and 2.4 mg per kg of body weight for children.

How does it work?

Motilium works by using its active ingredient domperidone, which is a dopamine receptor antagonist. Dopamine plays an important role in regulating gastrointestinal motility, and its effect on certain receptors can slow down the work of the stomach and intestines. Domperidone blocks these receptors, which helps to increase peristalsis and improve the digestion process.

In addition, domperidone increases the tone of the lower esophageal sphincter, which helps prevent reflux, and accelerates gastric emptying. This is especially important in conditions where food is retained in the stomach, causing unpleasant symptoms such as heaviness, bloating, and nausea. Thanks to these properties, Motilium helps relieve the symptoms of dyspepsia and other gastrointestinal disorders associated with impaired motility.

Indications

Motilium is used to treat and relieve symptoms of various gastrointestinal disorders that are associated with impaired motility of the stomach and intestines. This drug is prescribed to both adults and children, especially when symptoms such as nausea and vomiting appear, as well as other digestive disorders.

The main indications for Motilium include:

• Chronic and acute nausea and vomiting of various origins, including postoperative nausea, vomiting caused by chemotherapy or drugs.
• Dyspepsia, accompanied by a feeling of heaviness, bloating, heartburn and discomfort in the upper abdomen.
• Gastroparesis - slow emptying of the stomach, especially in patients with diabetes.
• Reflux esophagitis - inflammation of the esophagus associated with the reflux of acid from the stomach.

The drug can also be used for other conditions, as prescribed by a doctor, if its use will help improve gastrointestinal motility and eliminate the associated symptoms.

Contraindications

Despite the effectiveness of Motilium in treating various gastrointestinal disorders, its use is not always safe. There are certain contraindications in which the use of the drug can be harmful to health. It is important to carefully read these restrictions and consult a doctor before starting treatment.

The main contraindications for the use of Motilium include:

• Hypersensitivity or allergy to domperidone or any of the auxiliary components of the drug.
• Severe liver dysfunction, since domperidone is metabolized in the liver, and its use can increase the load on this organ.
• Prolactinoma is a hormonally active tumor of the pituitary gland, since domperidone can increase the level of prolactin in the blood.
• Serious heart rhythm disorders, such as prolongation of the QT interval, or the presence of other risk factors for the development of arrhythmia.
• Concomitant use with drugs that prolong the QT interval or inhibitors of the CYP3A4 enzyme, which can increase the risk of side effects.

Side effects

Although Motilium is generally well tolerated, like any other drug, it can cause side effects. These adverse reactions may occur to varying degrees in different people, depending on the individuals body and health condition. It is important to be aware of possible side effects and to report any unusual symptoms to your doctor while taking the drug.

Possible side effects of Motilium include:

• Headaches are one of the most common reactions that may occur with prolonged use.
• Dry mouth – sometimes occurs as a reaction to the drug, especially with prolonged treatment.
• Problems with stool – such as constipation or diarrhea, although they are less common.
• Increased prolactin levels – can lead to symptoms such as galactorrhea (milk secretion from the mammary glands outside the lactation period) or menstrual irregularities in women.
• Allergic reactions – rash, itching, swelling, which require immediate discontinuation of the drug and consultation with a doctor.