Mestinon - Pyridostigmine

What is it?

Composition

Mestinon is a drug with a unique composition aimed at improving neuromuscular transmission. The active substance is pyridostigmine bromide, which provides its main therapeutic effect. In addition to the main component, the composition also contains excipients that help create the necessary form of the drug and its stability.

• Pyridostigmine bromide is an active substance that inhibits the destruction of acetylcholine, which improves the functioning of the neuromuscular system.
• Lactose monohydrate is used to give the tablet structure.
• Corn starch ensures uniform distribution of the components.
• Talc and magnesium stearate facilitate easy swallowing and prevent sticking.

The composition is designed to not only be effective, but also suitable for most patients, except in cases of individual intolerance.

How to use?

To get the most benefit from using Mestinon, it is important to follow the instructions for use. The drug is available in various forms, including tablets and solutions, which makes it convenient for different patients. It is usually prescribed depending on the severity of symptoms, age and other individual characteristics.

1. The drug is taken orally, preferably with a small amount of water.
2. The dosage and frequency of administration depend on the doctors recommendations. The standard starting dose for adults can be 60 mg several times a day.
3. For children, the dosage is calculated depending on body weight and the severity of the condition.
4. It is important to take the medicine at regular intervals to maintain a stable level of the substance in the body.
5. If you miss a dose, take the dose as soon as possible, but do not double the next one.

Before starting treatment, you should always consult a doctor to avoid misuse or overdose.

How does it work?

The action of the drug Mestinon is based on its ability to inhibit the enzyme acetylcholinesterase. This enzyme is responsible for the destruction of acetylcholine, a substance that transmits nerve impulses from nerves to muscles. By suppressing its activity, the drug promotes the accumulation of acetylcholine, which improves signal transmission and enhances muscle contraction.

This is especially important in myasthenia gravis, where neuromuscular transmission is impaired. Mestinon helps restore balance in this system, reducing muscle weakness and increasing endurance. The effect of the drug appears shortly after administration, which makes it useful for controlling symptoms throughout the day.

Its action is gentle and long-lasting, which allows for uniform relief of symptoms. Thanks to this, patients can return to normal activity, minimizing the discomfort associated with their condition.

Indications

Indications for the use of Mestinon include conditions associated with disorders of neuromuscular transmission and bowel function. The drug is used as a drug of choice in several diseases where it is necessary to maintain adequate transmission of nerve impulses.

• Myasthenia gravis is the main indication for which the drug helps to eliminate muscle weakness and increase endurance.
• Paralytic intestinal obstruction - improves intestinal tone and peristalsis, eliminating symptoms of the disorder.
• Atony of the bladder - restores the ability of the organ to normal contraction and urination.

The drug can also be used in a number of cases requiring stimulation of muscle activity, for example, after surgery, when the muscles have temporarily lost tone. Its effectiveness and versatility make it an important tool in neurological and gastroenterological practice.

Contraindications

Like any other drug, Mestinon has a number of contraindications that must be taken into account before starting treatment. Ignoring these factors can lead to undesirable consequences and worsening of the patients condition.

• Hypersensitivity or allergy to pyridostigmine bromide or other components of the drug.
• Mechanical intestinal or urinary obstruction, where stimulation of peristalsis can aggravate the condition.
• Bronchial asthma, since the drug can increase bronchospasm.
• Severe heart failure or bradycardia (slow heart rate), which is associated with the effect on the parasympathetic nervous system.

Before using the drug, it is important to undergo a thorough medical examination and inform the doctor about all existing diseases. This will help to avoid possible complications and make the treatment safe and effective.

Side effects

Like many medications, Mestinon can cause side effects that are related to its effect on the neuromuscular and autonomic systems. Most of them occur when the dosage is exceeded or due to individual sensitivity to the drug.

• Gastrointestinal disorders such as nausea, vomiting, diarrhea, or abdominal cramps.
• Increased salivation or sweating associated with activation of the parasympathetic nervous system.
• Slow heart rate (bradycardia) or a feeling of weakness.
• Allergic reactions, including itching, rash, or swelling.
• Muscle twitching or cramps, especially in case of overdose.

If unpleasant symptoms appear, it is important to consult a doctor immediately. Adjusting the dosage or discontinuing the drug may help manage side effects and restore the patients comfort.