Lopid

Active ingredients: Gemfibrozil

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What is it?

Lopid is the trade name of a drug containing the active substance gemfibrozil. It belongs to a group of fibrates and is used to lower blood lipids, such as triglycerides and cholesterol. The drug is prescribed to patients with hyperlipidemia, especially when other treatments, including diet and exercise, have not been effective. Lopid helps reduce the risk of developing cardiovascular diseases associated with high levels of fats in the blood.

Composition

Each Lopid tablet contains 600 mg or 900 mg of gemfibrozil as the active ingredient. Additional ingredients include:

Gluten-free corn starch
Colloidal anhydrous silicon dioxide (E-551)
Polysorbate 80 (E-433)
Magnesium stearate (E-572)
Sodium carboxymethyl starch
Precipitated silicon dioxide

The tablet shell consists of hypromellose (E-464), titanium dioxide (E-171), macrogol 6000, simethicone (E-900) and talc (E-553(b)).

How to use?

Before starting to take Lopid, it is important to consult with your doctor to determine the optimal dosage and regimen. The following regimen is usually recommended:

Take the drug orally with plenty of water.
The dosage is 900-1200 mg per day, divided into two doses.
Tablets should be taken half an hour before meals, usually before breakfast and dinner.

It is important to strictly follow the doctors instructions and not change the dosage without consultation. If a dose is missed, the tablet should be taken as soon as possible, but do not double the dose at the next dose.

How does it work?

Gemfibrozil, the active ingredient in Lopid, works by lowering the levels of triglycerides and very low-density lipoproteins (VLDL) in the blood. It stimulates lipolysis, the process of breaking down fats in the body, which leads to a decrease in the concentration of harmful lipids. In addition, the drug helps to increase the level of high-density lipoproteins (HDL), known as good cholesterol, which has a beneficial effect on the patients overall lipid profile.

Indications

Lopid is indicated for:

Severe hypertriglyceridemia with low HDL.
Mixed hyperlipidemia when statins are contraindicated or not tolerated.
Primary hypercholesterolemia when statins are not tolerated.
Prevention of cardiovascular disease in men with high non-HDL cholesterol and high risk of first cardiovascular event when statins are contraindicated or not tolerated.

Contraindications

The drug should not be taken in the following conditions:

Allergy to gemfibrozil or other components of the drug.
Severe liver failure.
Severe renal failure.
Gallbladder disease, including cholelithiasis.
Concomitant use with repaglinide, dasabuvir, selexipag, simvastatin, or rosuvastatin at a dose of 40 mg.
History of photosensitivity or phototoxic reactions to fibrates.

Side effects

The following side effects are possible when taking Lopid:

Headaches and dizziness.
Dyspepsia, abdominal pain, diarrhea, nausea, vomiting, constipation.
Eczema, rash, itching.
Fatigue.
Rare: myositis, myopathy, rhabdomyolysis, pancreatitis, cholelithiasis, cholecystitis, depression, decreased libido, visual impairment, anemia, leukopenia, thrombocytopenia.

If any adverse reactions occur, consult a doctor immediately.