Forxiga - Dapagliflozin

What is it?

Composition

The main active ingredient in Forxiga is dapagliflozin. Excipients include:

• Microcrystalline cellulose, which provides the structure of the tablet.
• Lactose, which helps form the tablet and improves its stability.
• Croscarmellose sodium, which promotes rapid disintegration of the tablet in the stomach.
• Magnesium stearate, used as a lubricant for tablets.
• Opadry (hydroxypropyl methylcellulose, titanium dioxide), which serves as a coating for the tablet.

How to use?

Forxiga is taken orally, with or without food. Tablets should be swallowed whole with plenty of water. The standard dosage is one 10 mg tablet per day, but may be adjusted by your doctor depending on your individual indications and condition.

Basic recommendations for use:

1. Take the drug at the same time every day to maintain a stable level of dapagliflozin in the body.
2. Do not skip doses or double the next dose if you miss one.
3. Follow your doctors instructions regarding dosage and duration of treatment.

How does it work?

Forxiga works by inhibiting the sodium-glucose cotransporter type 2 (SGLT2) in the kidneys, which prevents the reabsorption of glucose and promotes its excretion in the urine. This leads to a decrease in blood glucose levels, which helps in the management of type 2 diabetes. In addition, the drug reduces the load on the heart and kidneys, improving their function and reducing the risk of developing cardiovascular diseases and the progression of chronic kidney disease in patients with diabetes.

Indications

Forxiga is indicated for the treatment of the following conditions:

• Type 2 diabetes mellitus, as monotherapy or in combination with other hypoglycemic agents.
• Chronic heart failure, to reduce the risk of cardiovascular complications.
• Chronic kidney disease, to slow the progression of the disease and reduce the risk of renal failure.

The drug is intended for use in adult patients when improved blood glucose control or reduced risks associated with cardiovascular and renal complications are required.

Contraindications

Forxiga is contraindicated in the following conditions:

• Hypersensitivity to dapagliflozin or any of the components of the drug.
• Patients with type 1 diabetes mellitus, since the risk of diabetic ketoacidosis is increased.
• Patients with severe renal impairment (CC < 25 ml / min) or with end-stage renal failure.
• Pregnancy and lactation, due to insufficient safety data.

Side effects

Forxiga may be associated with some side effects, including:

• Urinary tract infections, such as cystitis.
• Hypoglycemia, especially when combined with insulin or sulfonylureas.
• Dehydration and decreased blood pressure, which may lead to dizziness or fainting.
• Increased risk of diabetic ketoacidosis, especially in patients with type 1 diabetes.

If any adverse reactions occur, consult your doctor to adjust your therapy.