Dostinex - Cabergoline

What is it?

Composition

Dostinex contains the active substance cabergoline, which is the main component of the drug. Cabergoline is a powerful dopaminergic agent that affects the production of prolactin in the pituitary gland. Its action is aimed at stimulating dopamine receptors, which leads to a decrease in prolactin secretion.

In addition to cabergoline, Dostinex contains excipients that ensure the stability of the drug and ease of use:

• Lactose anhydrous
• Leucine

These components act as a filler and stabilizer, helping to maintain the shape of the tablets and ensure uniform release of the active substance.

How to use?

To achieve the best results, it is important to follow the Dostinex instructions correctly. Usually, the dosage and duration of treatment depend on the specific disease and the level of prolactin in the body, so the dosage is always prescribed by a doctor.

Dostinex is usually taken orally during meals to minimize possible side effects from the gastrointestinal tract. The tablets should be taken with a sufficient amount of water.

Basic recommendations for use:

1. The starting dose is usually 0.25 mg twice a week.
2. The dose can be gradually increased, depending on the prolactin level and the bodys response to treatment.
3. The maximum dose should not exceed 1 mg twice a week.
4. The duration of treatment is determined by the doctor and can vary from several weeks to several months, depending on the effect achieved.

How does it work?

Dostinex works due to the active substance cabergoline, which is a dopamine receptor agonist. Cabergoline binds to D2-dopamine receptors in the pituitary gland, which leads to a decrease in prolactin secretion. This process is important for the correction of conditions caused by hyperprolactinemia, such as menstrual irregularities in women and decreased libido in men.

The drug has a long-term effect, due to which the prolactin level begins to decrease within a few hours after administration and can remain low for several days. This ensures a stable condition of the patient, eliminating symptoms associated with excess prolactin and improving the overall quality of life. Dostinex can also help reduce the size of prolactinoma, which is a significant advantage in the treatment of this disease.

Indications

Dostinex is used in various medical situations associated with elevated prolactin levels in the body. The main indications for its use include:

• Treatment of hyperprolactinemia, which can cause menstrual irregularities, infertility, and galactorrhea (unwanted lactation) in women.
• Elimination of hyperprolactinemia in men, which helps to cope with libido problems and erectile dysfunction.
• Treatment of prolactinoma - a pituitary tumor that produces prolactin, which can lead to various endocrine disorders.
• Stopping lactation in women when it is necessary for medical reasons, such as after the loss of a child or for other medical reasons.

Dostinex effectively reduces prolactin levels, which helps to normalize hormonal balance and eliminate the symptoms caused by its excess.

Contraindications

Although Dostinex is an effective drug, its use is contraindicated in a number of cases. The main contraindications include:

• Hypersensitivity to cabergoline or any of the excipients of the drug.
• The presence of fibrotic changes in the tissues of the heart, lungs or abdominal cavity, since the drug can aggravate these conditions.
• Severe liver dysfunction, which can slow the elimination of the drug from the body.
• Uncontrolled hypertension (high blood pressure), especially during pregnancy or after childbirth.
• History of psychotic disorders, since Dostinex can increase such symptoms.

Before starting treatment, it is important to discuss all possible contraindications with your doctor to avoid unwanted health consequences.

Side effects

Although Dostinex is generally well tolerated, some patients may experience side effects. These most often occur in the first weeks of treatment and may subside as the body adapts to the drug. The most common side effects include:

• Dizziness, especially when standing up from a lying or sitting position.
• Headache and fatigue.
• Nausea, sometimes accompanied by vomiting.
• Abdominal pain or dyspepsia (indigestion).
• Constipation or, less commonly, diarrhea.

In rare cases, more serious reactions are possible, such as fibrotic changes in tissue, mental disorders, or a significant decrease in blood pressure. If unusual or persistent symptoms occur, you should immediately consult a doctor for evaluation and possible treatment adjustments.