Crestor - Rosuvastatin

What is it?

Composition

The main active ingredient in Crestor is rosuvastatin calcium. This compound belongs to the group of statins, which lower cholesterol by inhibiting the enzyme HMG-CoA reductase, a key component in the synthesis of cholesterol in the liver. Depending on the form of release, the drug may contain rosuvastatin in different dosages, for example, 5, 10, 20 or 40 mg.

Excipients may include:

• Lactose monohydrate
• Microcrystalline cellulose
• Calcium phosphate
• Crospovidone
• Magnesium stearate
• Opadry (film coating of tablets)

These components ensure the stability, form and ease of use of the drug, and also contribute to its effective absorption in the body.

How to use?

Correct use of Crestor is essential for achieving the best results. Take the medicine orally with plenty of water. Do not chew or break the tablet, as this may affect its effectiveness. Crestor can be taken at any time of day, regardless of food intake, but it is recommended to take it at the same time every day to maintain a stable level of the active substance in the body.

Follow your doctors instructions regarding dosage and duration of treatment. Treatment is usually started with a low dose, which can then be increased depending on the bodys response and cholesterol levels. It is important to remember that:

1. The initial dose is usually 5-10 mg once a day.
2. Depending on cholesterol levels and treatment goals, the dose can be increased to 20-40 mg per day.
3. Do not change the dosage on your own without consulting your doctor.

Regular medical examinations and blood tests will help monitor the effectiveness of treatment and minimize the risk of side effects.

How does it work?

Crestor works by lowering blood cholesterol levels by inhibiting the activity of the enzyme HMG-CoA reductase, which plays a key role in the synthesis of cholesterol in the liver. This process leads to a decrease in the production of bad cholesterol (LDL), which reduces the risk of atherosclerotic plaque formation in the arteries. As a result, the arteries remain more open and flexible, which improves blood flow and reduces the likelihood of cardiovascular diseases such as heart attack or stroke.

In addition to lowering LDL levels, Crestor also increases the concentration of good cholesterol (HDL) and helps reduce triglyceride levels. This complex effect helps in the fight against atherosclerosis and improves the patients overall lipid profile. It is important to understand that the action of Crestor is part of a comprehensive approach to treatment, which also includes changes in diet and lifestyle.

Indications

Crestor is primarily used to lower total cholesterol and LDL cholesterol in patients with hypercholesterolemia. The drug is indicated for those who have not been able to achieve normal lipid profiles through diet and exercise. Crestor can be prescribed for the treatment of both adults and children aged 10 years and older if they have been diagnosed with a hereditary form of hypercholesterolemia.

In addition, Crestor is used to prevent cardiovascular disease in patients at high risk for developing it. This is especially important for people with existing risk factors such as diabetes, hypertension, smoking, or a family history of cardiovascular disease. The drug is also indicated for the treatment of atherosclerosis to slow the progression of the disease and reduce the risk of complications.

• Hypercholesterolemia and mixed dyslipidemia
• Familial hypercholesterolemia (heterozygous and homozygous)
• Prevention of cardiovascular disease in patients at high risk
• Treatment of atherosclerosis to slow its progression

Contraindications

Crestor has a number of contraindications that need to be taken into account before starting treatment. The drug should not be taken by people with hypersensitivity to rosuvastatin or any of the excipients of the drug. In addition, Crestor is contraindicated in active liver diseases such as hepatitis or cirrhosis, as well as in persistently elevated transaminase levels in the blood, as this may indicate liver problems.

Other contraindications include severe renal failure and myopathy, as well as a condition in which there is a risk of rhabdomyolysis - the destruction of muscle fibers, which can lead to serious complications, including kidney failure. Women during pregnancy and breastfeeding are also prohibited from taking Crestor, as it may cause harm to the fetus or infant. Crestor is also not recommended for use in patients taking cyclosporine, as this can significantly increase the risk of serious side effects.

• Hypersensitivity to rosuvastatin or excipients
• Active liver disease
• Pregnancy and lactation
• Severe renal impairment
• Myopathy or risk of rhabdomyolysis
• Concomitant use of cyclosporine

Side effects

Like any other drug, Crestor can cause side effects, although most patients tolerate it well. The most common side effects are related to the muscular system and the digestive tract. Some patients may experience muscle pain, weakness, or even muscle cramps. These symptoms may indicate myopathy, especially if they are accompanied by an increase in creatine kinase levels in the blood.

Side effects from the digestive system may include nausea, constipation, abdominal pain, or diarrhea. In rare cases, more serious side effects may develop, such as liver inflammation (hepatitis) or jaundice. It is also worth considering that some patients may experience allergic reactions, manifested in the form of skin rashes, itching, or swelling of the face.

If you experience any of these symptoms, especially severe muscle pain or signs of an allergic reaction, you should immediately consult a doctor.

• Muscle pain, weakness, or cramps
• Nausea, constipation, abdominal pain
• Hepatitis or jaundice (rare)
• Allergic reactions such as rash or swelling of the face