Celebrex - Celecoxib

What is it?

Composition

Celebrex contains the active substance celecoxib, which is responsible for the main therapeutic effect of the drug. In addition, the capsules contain auxiliary components that help ensure the stability and absorption of the drug in the body. All components are carefully balanced to achieve maximum effectiveness and safety.

The main ingredients in the capsule:

• Celecoxib (active substance)
• Lactose monohydrate
• Croscarmellose sodium
• Poloxamer
• Magnesium stearate
• Gelatin (capsule shell)
• Titanium dioxide (dye)

How to use?

Celebrex should be used strictly according to the doctors recommendations. The dosage and duration of treatment depend on the specific disease and individual characteristics of the patient. It is important to remember that exceeding the recommended dose may increase the risk of side effects, especially from the cardiovascular system and gastrointestinal tract.

General procedure for use:

1. Take the capsules whole with plenty of water.
2. It is recommended to take the drug during meals to minimize the risk of stomach irritation.
3. The standard dosage for adults is usually 100 to 200 mg once or twice a day.
4. The course of treatment is determined by the doctor and can vary from several days to several weeks depending on the severity of the condition.

How does it work?

Celebrex works by inhibiting the activity of the cyclooxygenase-2 (COX-2) enzyme, which plays a key role in the synthesis of prostaglandins – substances involved in the development of inflammation, pain and increased body temperature. Due to the selective inhibition of COX-2, the drug effectively reduces inflammation and pain without affecting cyclooxygenase-1 (COX-1), which is necessary to protect the gastric mucosa.

This mechanism of action makes Celebrex less aggressive towards the gastrointestinal tract compared to non-selective NSAIDs, which reduces the risk of ulcers and erosions. In addition, due to this selective effect, the drug retains its effectiveness with long-term use, especially in patients with chronic inflammatory diseases.

Indications

Celebrex is used to treat various inflammatory and painful conditions, especially when long-term therapy is required. The drug is prescribed in the following cases:

• Osteoarthritis - to relieve pain and inflammation associated with this degenerative joint disease.
• Rheumatoid arthritis - to reduce inflammation and relieve pain in patients with chronic autoimmune disease.
• Ankylosing spondylitis - to relieve symptoms of inflammation and pain in the spine and other joints.
• Pain syndrome of various origins - to relieve acute or chronic pain, including postoperative conditions.

Contraindications

Despite the effectiveness of Celebrex, there are certain conditions in which the use of the drug is contraindicated. Given the possible risks, it is important to discuss any existing medical conditions with your doctor before starting treatment. The main contraindications include:

• Hypersensitivity to celecoxib or any other components of the drug.
• Allergy to sulfonamides, since celecoxib is chemically related to this group of substances.
• Severe heart failure, coronary artery disease, or peripheral arterial disease.
• Active ulcers or bleeding in the gastrointestinal tract.
• Severe liver or kidney dysfunction.
• Pregnancy, especially the third trimester, and the period of breastfeeding.

Side effects

Although Celebrex is considered safer for the gastrointestinal tract than other NSAIDs, its use may still be accompanied by side effects. It is important to closely monitor your condition during treatment and report any unwanted symptoms to your doctor.

The most common side effects include:

• Headache
• Nausea, stomach upset
• Increased blood pressure
• Dizziness
• Rash or skin reactions

In rare cases, more serious side effects may occur, such as cardiovascular complications or allergic reactions. Therefore, it is important to carefully follow your doctors instructions and not exceed the prescribed dosage.