Amaryl

What is it?

Composition

Amaryl is available in tablet form, containing the active substance glimepiride in various dosages. Each tablet also contains auxiliary components that ensure the stability and absorption of the drug.

• Glimepiride is the main active ingredient responsible for lowering blood sugar levels.
• Lactose monohydrate is used as a filler and stabilizer.
• Sodium starch glycolate (type A) promotes rapid disintegration of the tablet in the stomach.
• Microcrystalline cellulose provides the necessary structure of the tablet.
• Povidone acts as a binder.
• Magnesium stearate is used as a lubricating agent.
• Iron oxide yellow (E172) and indigotine aluminum lake (E132) are dyes that give the tablets their characteristic color.

The combination of these components ensures the effectiveness and stability of the drug, as well as the ease of its use.

How to use?

To achieve the maximum therapeutic effect and minimize the risk of side effects, it is important to strictly follow the doctors recommendations when using Amaryl. The dosage is selected individually, depending on the blood sugar level and the patients characteristics.

1. The initial dose is usually 1 mg of glimepiride per day. If necessary, the doctor can gradually increase the dose, monitoring the bodys reaction.
2. The tablet should be taken orally with a sufficient amount of water, preferably before the first meal or during breakfast.
3. If the patient misses a dose, the next one should not be doubled. It is necessary to continue taking it according to the prescribed schedule.

Regular measurement of blood glucose levels helps to adjust the treatment. It is not recommended to change the dose or stop taking the drug without consulting a doctor.

How does it work?

Amaryl works by stimulating the pancreas to produce more insulin, which is especially important for patients with type 2 diabetes. Its active ingredient, glimepiride, interacts with receptors in the beta cells of the pancreas, increasing sensitivity to glucose.

The drug also affects peripheral tissues, such as muscle and adipose tissue, improving their ability to absorb glucose. This helps lower blood sugar levels not only during meals, but also between meals.

Amaryl has a prolonged effect, which allows you to maintain a stable glucose level throughout the day with a single dose. Its effectiveness is combined with a relatively low risk of sharp jumps in sugar or hypoglycemia, especially with the correct dosage and diet.

Indications

Amaryl is used to treat patients with type 2 diabetes mellitus when diet, physical activity, and weight control do not allow them to achieve the required blood sugar level. This drug is effective as an independent agent or in combination with other hypoglycemic drugs.

• Type 2 diabetes mellitus (insulin-independent) in adults.
• The need to maintain a stable blood glucose level throughout the day.
• The need for combination with insulin or metformin to enhance the effect of therapy.

Amaryl helps patients avoid complications of diabetes, such as vascular disorders and damage to target organs (eyes, kidneys, heart), provided that the doctors recommendations are followed.

Contraindications

Amaryl is not recommended for use in a number of cases associated with individual characteristics of the body or the patients condition. Neglect of these contraindications may lead to undesirable consequences and deterioration of health.

• Type 1 diabetes mellitus (insulin-dependent).
• Diabetic ketoacidosis, precomatose conditions or diabetic coma.
• Severe liver or kidney dysfunction.
• Individual intolerance to glimepiride or other components of the drug.
• Pregnancy and breastfeeding periods.
• Age under 18 years (efficacy and safety have not been established).

Before starting treatment, it is important to inform your doctor about any chronic diseases, medications taken or allergic reactions in order to exclude possible risks.

Side effects

Like any other drug, Amaryl can cause side effects, although not all patients experience them. Most often, adverse reactions are associated with an incorrectly selected dosage or individual sensitivity to the components of the drug.

• Hypoglycemia: decreased blood sugar levels, accompanied by dizziness, weakness, sweating, palpitations.
• Digestive system disorders: nausea, abdominal pain, diarrhea or, conversely, constipation.
• Allergic reactions: skin rash, itching, rarely - anaphylactic reactions.
• Visual impairment: temporary deterioration of vision associated with changes in glucose levels.
• Hematological changes: decreased platelet count, leukopenia or anemia.

If any adverse reactions occur, you must immediately consult a doctor. Particular attention should be paid to the symptoms of hypoglycemia, which can be dangerous if not treated promptly.